The instruments which underlie the impact of psychostimulants in ADHD or deficit in attention hyperactivity disorder are not properly agreed; however D2 dopamine receptors are indicated by the indirect evidence. In the study, in order to identify post and presynaptic elements which are necessary for are impacts of amphetamine in the mice the constituents of dopaminergic neurotransmission are dissected of the hyperactive mouse mutant coloboma. In coloboma mice, the locomotoraction was abridged by the amphetamine treatment. However, a sharp rise in the overflow of dopamine was seen which suggest that behavioral effect is not due to the dopamine efflux (Hu and Wang 1988). But, the amphetamine-induced decrease in locomotoraction in coloboma mice was not blocked by the D1-like dopamine receptor antagonist SCH23390 but was jammed by the D2-like dopamine receptor antagonists’ haloperidol and raclopride. This shows that the impact of amphetamine in these mice is arbitrated by the D2-like dopamine receptors. In this study it shows that due to the fact that it is likely to antagonize directly this reaction would be useful in the identification of identifying novel therapeutics in ADHD.