关于知情同意的概念，出现了许多心理问题。与知情同意相关的问题或挑战之一是语言障碍。由于语言翻译方法的不恰当，有时会造成个人观点的误解。这种情况在治疗过程中增加了研究者或医生的责任。个体的宗教方面可以作为参与治疗或研究过程的障碍，因为通过个体宗教设定的行为规则可能会影响接受治疗(Bowman et al.， 2011)。此外,错误预期的心理问题也可以知情同意作为治疗的病人可能担心他或她可能被视为一个实验模型研究或研究,或病人可以拒绝,因为历史事实的不端行为或欺诈行为由特定的诊所。有时，由于患者对试验费用的感知，或者由于提供了大量关于试验风险或副作用的信息，患者害怕开始试验，因此很难获得知情同意，患者也可以拒绝。因担心医疗费用超出保险范围，患者可拒绝治疗或拒绝同意。这些心理问题可以作为获得患者知情同意的障碍。
There are number of psychological problems which arise with regards to the concept of informed consent. One of the issues or challenges related with informed consent is the language barrier. As sometime, misunderstanding individual’s viewpoint can occur due to the inappropriate method of language translations. This situation raises the responsibility of the researcher or the doctor when the treatment process is going on. Religious aspects of the individuals can act as barrier for participating in the treatment or research process as the behaviour rule set through the individual’s religion may influence to accept the medical treatment ( Bowman et al., 2011). In addition to this, false expectations can also be a psychological problem with the informed consent as the patient may fear of treatment as he or she may be treated as an experimental model for a research or study, or patient can refuse because of the historical facts of the misconducts or frauds done by that particular clinic. Sometimes, receiving informed consent becomes difficult due to the patient’s perception about expense on trials, or the vast information given on the risk of the trials or the side-effects can make the patients fear to start the trail and he or she can refuse. Patients can refuse for the treatment or deny to give consent as they have fear concerning to the medical expenses that may not be covered by their insurance. These psychological problems can act as barrier in obtaining informed consent from the patients.